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GROWTH HORMONE, HUMAN

GROWTH HORMONE, HUMAN

CAS: 12629-01-5

Molecular Formula: C990H1529N263O299S7

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GROWTH HORMONE, HUMAN - Names and Identifiers

Name GROWTH HORMONE, HUMAN
Synonyms HGH
10IU
cb311
HGH 10IU
Growth hormone 1
GROWTH HORMONE, HUMAN
SoMatotropin (huMan)(9CI)
Growth Hormone from chicken
Recombinant human somatotropin
CAS 12629-01-5
EINECS 235-735-8

GROWTH HORMONE, HUMAN - Physico-chemical Properties

Molecular FormulaC990H1529N263O299S7
Molar Mass22124.12
Specific Rotation(α)25 -38.7° (0.1M acetic acid)
Appearancelyophilized powder
Storage Condition2-8°C
UseSummary The human growth hormone (GH) is a single-chain, non-glycated, hydrophilic globulin of 191 amino acids with a molecular weight of 21700Da and an isoelectric point pI of 4.9. At positions 53 and 165 and 182 and 189 cysteine residues are linked by disulfide bonds; Approximately 75% of the growth hormone secreted by the eosinophils of the anterior pituitary gland is secreted in the form of this molecular structure, another 5-10% is secreted in the form of molecular weight 20kDa.

GROWTH HORMONE, HUMAN - Risk and Safety

WGK Germany3
RTECSTO7385000
HS Code2937110000
ToxicityLD50 oral in rat: 160iu/kg

GROWTH HORMONE, HUMAN - Reference Information

Open Data Unverified Data
Overview human Growth hormone (GH) is a single-chain, non-glycosylated, A hydrophilic globulin consisting of 191 amino acids with a molecular weight of 21700Da and an isoelectric point pI of 4.9. At positions 53 and 165 and 182 and 189 cysteine residues are linked by disulfide bonds; Approximately 75% of the growth hormone secreted by the eosinophils of the anterior pituitary gland is secreted in the form of this molecular structure, another 5-10% is secreted in the form of molecular weight 20kDa.
secretion spontaneous secretion of hGH in a paroxysmal form, it usually occurs in the first slow wave sleep period (SWS) after physiological sleep. Rest during the day may promote the release of hGH, feeding, fasting, exercise and stress can affect the secretion of hGH, but does not change its basic rhythm; Adolescent hGH secretion amplitude, frequency, the total amount of diurnal secretion is large, while the elderly are the opposite.
properties human growth hormone pre-hormone is composed of growth hormone naturally present in bacteria, linked to a signal peptide. The prohormone divides in the inner wall of the cell of the bacterium, releasing the same final product as the natural growth hormone into the intramural membrane space, and then only destroying the outer wall of the cell to collect, while the inner wall of the cell remains intact, in order to ensure that there is little bacterial protein contamination of the final product.
Last Update：2024-04-09 19:43:38

GROWTH HORMONE, HUMAN - Effect of recombinant human growth hormone on protein metabolism in patients with chronic abdominal infection

Open Data Unverified Data

from VIP

Author:

Li Yuanxin , Li Yousheng , Ren Jianan Li-Ning , Li Jianxiong

Abstract:

Objective: to study the effect of recombinant human growth hormone on protein metabolism in patients with chronic abdominal infection. Methods: Twenty patients with chronic abdominal infection were randomly divided into GH group (TPN GH) and control group (TPN). Infection score, serum growth hormone (GH), serum insulin-like growth factor -1(IGF-1), serum insulin-like growth factor binding protein -3(IGFBP-3); Serum albumin, prealbumin, transferrin, fibronectin, C- reactive protein; Determination of daily nitrogen balance and 24 h urine creatinine. Results: at the end of the study, GH,IGF-1,IGFBP-3 in the GH group were significantly higher than those in the control group and before the study, C- reactive protein decreased; Nitrogen balance improved, the cumulative nitrogen balance was significantly higher than the control group, while 24 h urinary creatinine decreased. Conclusion: recombinant human growth hormone can promote protein metabolism in patients with chronic abdominal infection, and IGF-1 plays an important role in it.

stowed

Key words:

infection metabolism Growth hormone Serum Albumin

DOI:

10.3969/j.issn.1007-810X.2001.01.002

cited:

59

year:

2001

Last Update：2024-04-09 19:43:38

GROWTH HORMONE, HUMAN - Recombinant human growth hormone promotes angiogenesis in hepatocellular carcinoma in vitro

from VIP Journal Professional Edition

Author:

Wang Ying , Li Suyi

Abstract:

objective: to observe the effect of recombinant human growth hormone (rhGH) on the proliferation of human umbilical vein endothelial cells (ECV) co-cultured with hepatoma cell lines expressing different growth hormone receptors (GHR). Methods: The GHR positive and negative cell lines were screened by immunocytochemistry and co-cultured with ECV. The intervention was performed with different concentrations of rhGH(50 and 250ng/mL, blank control). The proportion of cell cycle was detected by flow cytometry. The concentration of vascular endothelial growth factor (VEGF) secreted by hepatoma cells was determined by ELISA, and the cell growth curve was drawn. Results: Bel-7402(GHR positive) increased the level of VEGF secretion after rhGH intervention, and the growth of ECV co-cultured with rhGH was accelerated, and the proportion of S phase cells was significantly increased in a concentration-dependent manner (P 〈 0.05).. While SMMC-7721(GHR negative) could promote ECV proliferation, but was not affected by rhGH, and the secretion of VEGF did not change (P 〉 0.05). Conclusion: rhGH can induce GHR() hepatoma cells to secrete VEGF and indirectly promote the proliferation of vascular endothelial cells.

stowed

Key words:

Growth hormone growth hormone receptor angiogenesis co-culture

DOI:

CNKI:SUN:CWCN.0.2008-04-003

cited:

19

year:

2008

Last Update：2023-08-16 22:05:47

GROWTH HORMONE, HUMAN - The role and prospect of recombinant human growth hormone in nutritional support of burn patients

from VIP Journal Professional Edition

Author:

dunelin , Cao Liping

Abstract:

growth hormone (GH) has been used in clinical burn for half a century. It was isolated from the bovine pituitary gland and named by Li zuohao, a Chinese Canadian scholar in the 40's of the 20th century. In 1956, Li Zuo made great efforts to purify human growth hormone (hGH), thus attracting many scholars, such as endocrinology, metabolism, nutrition and pathophysiology and other experts to conduct in-depth research, and has basically clarified its biochemical characteristics and physiological effects, growth hormone and other hormones and growth hormone secretion regulation mechanism, among them, the experimental studies on the growth promoting effect of GH in rats, dogs and monkeys are still authoritative literatures, and GH species specificity has been known, and has been included in the hormone replacement therapy of GH endocrine dysfunction [1].

Key words:

Growth hormone GH burn human growth hormone Nutrition immunology

DOI:

CNKI:SUN:ZHSA.0.2001-04-000

cited:

86

year:

2001

Last Update：2023-08-16 22:05:47
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Hubei YoungXin Pharmaceutical Tech Co.,Ltd.
Product Name: Somatotropin Request for quotation
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Tel: 0714-3999186
Email: 2853786052@qq.com
Mobile: 86+15671228036
QQ: 2853786052 Click to send a QQ message
Wechat: 15671228036
Hefei TNJ Chemical Industry Co.,Ltd.
Product Name: GROWTH HORMONE, HUMAN Request for quotation
CAS: 12629-01-5
Tel: 0086-551-65418684
Email: sales@tnjchem.com
　　　　 info@tnjchem.com
Mobile: 0086 189 4982 3763
QQ: 2881500840 Click to send a QQ message
Wechat: 0086 189 4982 3763
WhatsApp: 0086 189 4982 3763
Product List: View Catalog
Zouping Mingxing Chemical Co., Ltd.
Product Name: Somatotropin Request for quotation
CAS: 12629-01-5
Tel: 0086-13605431940
Email: xuli678323@126.com
Mobile: +86-13605431940
QQ: 56860987 Click to send a QQ message
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GROWTH HORMONE, HUMAN
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